CRISPR/Cas9-Edited iPSC Lines
Donor ID | Donor Genotype | Isogenic Genotype | Ngn2 Integration | Engineering Method* | Line Name | Neural Induction |
F11362 | R406W/WT | WT/WT | No | CRISPR | F11362.1Δ1C11, F11362.1Δ1B6 | Yes |
F11421 | R406W/WT | WT/WT | No | CRISPR | F11421.12Δ2A07 | Yes |
F11374 | R406W/WT | N/A | Yes | TALENs | NF11374.65 | Yes |
160311SBB1 | V337M/WT | WT/WT | No | CRISPR | GIH6C1Δ1E11 | Yes |
160311SBB2 | V337M/WT | WT/WT | No | CRISPR | GIH7C2Δ2B12, GIH7C2Δ2F02 | Yes |
ND32951A | V337M/WT | WT/WT | No | CRISPR | ND32951A.15Δ1B06, ND32951A.15Δ1C12 | Yes |
GIH36 | IVS10+16/WT | WT/WT | No | CRISPR | GIH36C2Δ1D01 | Yes |
F0510 | P301L/WT | WT/WT | No | CRISPR | F0510.2Δ2E7, F0510.2Δ2’H1 | Yes |
F0510 | P301L/WT | P301L/P301S | No | CRISPR | F0510.2Δ3A11, F0510.2Δ3A9 | Yes |
F0510 | P301L/WT | WT/P301S | No | CRISPR | F0510.2Δ3E10, F0510.2Δ4B3, F0510.2Δ4B4 | Yes |
F0510 | P301L/WT | P301S/P301S | No | CRISPR | F0510.2Δ3B5 | Yes |
F0510 | P301L/WT | N/A | Yes | TALENs | NF0510.23, NF0510.12 | Yes |
75.11 | S305I/WT | WT/WT | No | CRISPR | 75.11-IW1A12 | N/A |
75.11 | S305I/WT | S305I/S305I | No | CRISPR | 75.11-IH1B9 | N/A |
GP1.1 | S305S/WT | S305S/S305S | No | CRISPR | GP1.1-SH1G8 | N/A |
F13505 | WT/WT | S305I/WT | No | CRISPR | F13505.1-I1B10 | N/A |
F13505 | WT/WT | S305S/WT | No | CRISPR | F13505.1-S3H5 | N/A |
F11350 | WT/WT | WT/R5H | No | CRISPR | F11350.1.R5HΔ2F06 | N/A |
F11350 | WT/WT | WT/G389R | No | CRISPR | F11350.1.G389R.1C05ΔE03 | N/A |
F11350 | WT/WT | P301L/P301L | No | CRISPR | F11350.1.P301LΔ4A02, F11350.1.P301LΔ4A08 | N/A |
F12468 | WT/WT | N/A | Yes | TALENs | NF12468.131 | Yes |
WTC11 | WT/WT | N/A | Yes | TALENs | NWTC11.G3 | Yes |
WTC11 | WT/WT | WT/WT | Yes | TALENs/CRISPR | NWTC11.G3.0036 | Yes |
WTC11 | WT/WT | V337M/WT | Yes | TALENs/CRISPR | NWTC11.G3.0212 | Yes |
WTC11 | WT/WT | V337M/V337M | Yes | TALENs/CRISPR | NWTC11.G3.3917 | Yes |
*Ngn2 was engineered by TALENs; MAPT mutations/corrections were engineered by CRISPR/Cas9
Please refer to our recent publication for more information:
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(19)30335-2