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 CRISPR/Cas9-Edited iPSC Lines

 

Donor ID Donor Genotype Isogenic Genotype Ngn2 Integration Engineering Method* Line Name Neural Induction
F11362 R406W/WT WT/WT No CRISPR F11362.1Δ1C11, F11362.1Δ1B6 Yes
F11421 R406W/WT WT/WT No CRISPR F11421.12Δ2A07 Yes
F11374 R406W/WT N/A Yes TALENs NF11374.65 Yes
160311SBB1 V337M/WT WT/WT No CRISPR GIH6C1Δ1E11 Yes
160311SBB2 V337M/WT WT/WT No CRISPR GIH7C2Δ2B12, GIH7C2Δ2F02 Yes
ND32951A V337M/WT WT/WT No CRISPR ND32951A.15Δ1B06, ND32951A.15Δ1C12 Yes
GIH36 IVS10+16/WT WT/WT No CRISPR GIH36C2Δ1D01 Yes
F0510 P301L/WT WT/WT No CRISPR F0510.2Δ2E7, F0510.2Δ2’H1 Yes
F0510 P301L/WT P301L/P301S No CRISPR F0510.2Δ3A11, F0510.2Δ3A9 Yes
F0510 P301L/WT WT/P301S No CRISPR F0510.2Δ3E10, F0510.2Δ4B3, F0510.2Δ4B4 Yes
F0510 P301L/WT P301S/P301S No CRISPR F0510.2Δ3B5 Yes
F0510 P301L/WT N/A Yes TALENs NF0510.23, NF0510.12 Yes
75.11 S305I/WT WT/WT No CRISPR 75.11-IW1A12 N/A
75.11 S305I/WT S305I/S305I No CRISPR 75.11-IH1B9 N/A
GP1.1 S305S/WT S305S/S305S No CRISPR GP1.1-SH1G8 N/A
F13505 WT/WT S305I/WT No CRISPR F13505.1-I1B10 N/A
F13505 WT/WT S305S/WT No CRISPR F13505.1-S3H5 N/A
F11350 WT/WT WT/R5H No CRISPR F11350.1.R5HΔ2F06 N/A
F11350 WT/WT WT/G389R No CRISPR F11350.1.G389R.1C05ΔE03 N/A
F11350 WT/WT P301L/P301L No CRISPR F11350.1.P301LΔ4A02, F11350.1.P301LΔ4A08 N/A
F12468 WT/WT N/A Yes TALENs NF12468.131 Yes
WTC11 WT/WT N/A Yes TALENs NWTC11.G3 Yes
WTC11 WT/WT WT/WT Yes TALENs/CRISPR NWTC11.G3.0036 Yes
WTC11 WT/WT V337M/WT Yes TALENs/CRISPR NWTC11.G3.0212 Yes
WTC11 WT/WT V337M/V337M Yes TALENs/CRISPR NWTC11.G3.3917 Yes

*Ngn2 was engineered by TALENs; MAPT mutations/corrections were engineered by CRISPR/Cas9

 

Please refer to our recent publication for more information:

https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(19)30335-2

Karch et al., A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies, Stem Cell Reports (2019), https://doi.org/10.1016/j.stemcr.2019.09.006

 

Stem Cells in the News

Neural Stem Cell Institute receives $300,000 grant for Research on Potential Cure for Macular Degeneration. Troy Record

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Our Unique Organization

The Neural Stem Cell Institute (NSCI) is dedicated to developing regenerative stem cell therapies for various diseases of the central nervous system (CNS): the brain, spinal cord and retina, regardless of the cause of injury. Led by MacArthur “Genius” Award winner Dr. Sally Temple who helped discover and define nervous system stem cells, NSCI is the first independent, non-profit stem cell research institute in the USA.

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Neural Stem Cell Institute
One Discovery Drive
Rensselaer, NY 12144

Phone: (518) 694-8188
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