Neural Stem Cell Institute, Rensselaer NY

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Xiuli Zhao M.D., Ph.D.

Dr. Zhao is interested in neurodegenerative and neuropsychiatric disorders research. In her graduate school in Arizona State University, she worked in Dr. Steve Macknic’s lab and found that hypoxia, caused by capillary constrictions in the hippocampus, contributes to neurodegeneration in epileptic mouse model 1. She completed her Ph.D. dissertation project in Dr. Amelia Gallitano’s lab. She found that the transcription factor early growth response 3 (EGR3) regulates the serotonin 2A receptor gene (Htr2a) probably through both direct and indirect ways 2,3. Identification of the mechanism could provide information for the proposed regulatory network which integrates genetic and environmental factors influences on schizophrenia and could provide future therapeutic targets to diagnose and treat schizophrenia. Currently, she is working on how the aging process contributes to changes in neural stem cell activity in the subventricular zone.

Publications:

  1. Leal-Campanario R, Alarcón-Martínez L, Rieiro H, Martinez-Conde S, Demirci T, Zhao X, LaMee L, Osborn P, Calhoun M, Arribas JI, Schlegel AA, Luigi Di Stasi L, Rho J, Inge L, Otero-Millan J, Treiman DM, Macknik SL. Abnormal Capillary Vasodynamics Contribute to Ictal Neurodegeneration in Epilepsy. Sci Rep. 2017; 7: 43276
  2. Maple AM, Zhao X, Elizalde DI, McBride AK, Gallitano AL. Htr2a Expression Responds Rapidly to Environmental Stimuli in an Egr3-Dependent Manner. ACS Chem Neurosci, 2015, 6(7): 1137-1142.
  3. Zhao X, Maple AM, Meyers KT, Marballi KK., McBride AK, Gallitano AL. Regulation of the Serotonin 2A Receptor Gene (Htr2a) by the Transcription Factor Early Growth Response 3 (EGR3) in the Mouse Cortex. In preparation

 

Stem Cells in the News

Neural Stem Cell Institute receives $300,000 grant for Research on Potential Cure for Macular Degeneration. Troy Record

Upcoming Events

September 30, 2016 5th Stem Cell Soiree Read More 

Blog

NSCI Female Scientists Inspiring Girls in Science!

September 7, 2018

Alima Ahmed, Student Volunteer at NSCI Wins Prestigious Award

August 27, 2018

Regenerative Eye Research- More Than Meets the Eye

June 8, 2018

Our Unique Organization

The Neural Stem Cell Institute (NSCI) is dedicated to developing regenerative stem cell therapies for various diseases of the central nervous system (CNS): the brain, spinal cord and retina, regardless of the cause of injury. Led by MacArthur “Genius” Award winner Dr. Sally Temple who helped discover and define nervous system stem cells, NSCI is the first independent, non-profit stem cell research institute in the USA.

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Neural Stem Cell Institute
One Discovery Drive
Rensselaer, NY 12144

Phone: (518) 694-8188
Fax: (518) 694-8187

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