The Tau Consortium is a highly collaborative international group of investigators studying Tauopathies, which are neurodegenerative diseases like Alzheimer’s Disease, in which a protein called Tau misfolds and accumulates in the brain. The Tau Consortium is funded by the Rainwater Charitable Foundation and is made up of scientists and clinicians working to understand what leads to Tauopathies and to develop treatments and ultimately cure these disorders. The Stem Cell Group of the Tau Consortium consists of investigators from the University of California, Harvard, Washington University and Mount Sinai, New York, who are focused on developing “disease in a dish” models to answer questions related to disease mechanism. One key resource from this work is a world-class collection of induced pluripotent stem cells (iPSCs) generated from blood samples or small skin biopsies donated by patients carrying mutations linked to tauopathies or by healthy individuals. Currently, the iPSC collection includes seven different MAPT mutations and lines from several donors with progressive supranuclear palsy (PSP). Our goal is to continue to expand the collection each year with new and interesting mutations that will add to the research enterprise. Work is underway to create corrected isogenic controls for several of these lines. In addition, we plan to include de novo MAPT mutations introduced into normal, healthy control lines.
The MAPT iPSC collections are now available to investigators in both for-profit and non-profit organizations. Please use the links below for more information about the collections, and the documentation process required to obtain these lines. Our recent publication on the cell lines is also available below.
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(19)30335-2
Process for Requesting Lines
All requests will be reviewed by the Tau Consortium’s Stem Cell Group. Typical request turn around time is 10 Business days, barring any delays from MTA execution, communication with PIs, and special requests that require an additional scope of work. Please submit the following:
- Tau Consortium Induced Pluripotent Stem Cell Request Form [Download Form]
- CV/Biosketch
- Research summary: specific aims, background, preliminary data, sample size justification
Upon approval, the required material transfer agreements must be signed prior to distribution. Please follow this link for more about on the collection’s scope, aim and additional information on the procedures for obtaining lines.
- UBMTA Implementing Letter [ Download Doc ]
- UBMTA Master Agreement [ Download Doc ]
Contact: Project Manager, Khadijah Onanuga Ph.D., PMP [ khadijahonanuga@neuralsci.org ] Cost: Please contact the Project Manager for pricing.
Click here for the:
Dermal Fibroblast Bank to Model Tauopathies |
Click here for the:
Tau Consortium iPSC Line Collection |
Click here for the:
Tau Consortium CRISPR/Cas9-Edited iPSC Line Collection |