The Regenerative Research Foundation/Neural Stem Cell Institute has open positions for research personnel.
Ophthalmology Clinical Trial Data Analyst
The Neural Stem Cell Institute (NSCI) is seeking a Clinical Data Analyst for a Phase 1/2a clinical trial of retinal pigment epithelium stem cell treatment of dry age-related macular degeneration (AMD) (Safety and tolerability of RPESC-RPE transplantation in patients with dry age-related macular degeneration: Low-dose clinical outcomes –PubMed). A highly motivated, mission-driven analyst will process outcome data from 18 subjects. Strong statistical and communication skills are essential to advance cutting-edge, best-in-class regenerative therapy for AMD patient benefit.
Responsibilities
- Collect and organize visual acuity and optical coherence tomography (OCT) data obtained at Stanford U and UMich clinical sites.
- Analyze outcomes following treatment.
- Generate graphical visualization of trial outcomes.
- Perform statistical analyses of outcomes.
- Correlate baseline and treatment outcome data.
- Correlate cell product characteristic data with clinical outcomes.
- Participate in planning a next Phase 2b trial.
Skills
- Proficiency in managing clinical trial data.
- Experience with multivariate statistical tools (Python, R, or equivalent).
- Strong visualization and graphical presentation skills.
- Familiarity with ophthalmic imaging, good clinical practice and HIPAA.
- Ability to communicate effectively with clinicians, biologists and bioinformaticians.
Education
- Bachelor’s or higher degree in Statistics, Biostatistics, Computer Science, Data Science, Bioinformatics, Biomedical Engineering, Life Sciences, or a related field.
Work Environment
NSCI is a dynamic environment dedicated to the development of stem cell therapies for nervous system diseases. You will work with a team of 4 trial investigators and 10 scientists to analyze Phase 1/2a trial outcomes. NSCI offices and laboratories are in a modern biotechnology building located in an active research community in Albany, NY (www.neuralsci.org). The position includes a full-benefit package.
To apply: Applicants should email their CV, a cover letter, and contact information for at least two references to brigittearduini@neuralsci.org. Please include “Clinical Trial Data Analyst Position” in the email subject line.
Postdoctoral Fellow Position – Development of Novel Intracellular Antibody Therapeutics for Neurodegenerative Disorders
We are seeking a highly motivated Postdoctoral Fellow to join the Butler lab. The primary focus of this position is to develop novel intracellular antibody (intrabody) therapeutics for neurodegenerative disorders caused by misfolded proteins, with the ultimate goal of advancing these therapeutics from preclinical to clinical pipelines.
Research:
Numerous neurodegenerative diseases, including Huntington’s Disease, Parkinson’s Disease, and Alzheimer’s Disease, share a common molecular pathway involving protein misfolding. This misfolding generates toxic species and triggers pathogenic cascades in the CNS. The Butler lab’s long-term goal is to develop immunotherapeutics that protect against these disorders by targeting mutant Huntington, synuclein, and tau proteins for degradation. Through recombinant antibody technologies, innovative bifunctional intrabody reagents will be developed to specifically prevent misfolding of neurodegenerative proteins. These reagents will direct the proteins into normal clearance pathways in iPSC-derived neurons, replicating disease phenotypes observed in the human brain. The research will employ advanced techniques such as CRISPR-edited iPSCs, iPSC-derived organoids, RNASeq/single-cell transcriptome analysis, immunoprecipitation, FACS sorting, and immunofluorescence.
Requirements:
The position requires a highly motivated individual with a PhD, MD, or MD/PhD degree who aspires to develop an independent research career.
The ideal applicant will possess:
- Protein Characterization: Skills in SDS-PAGE, Western blotting, ELISA, and immunoassays for assessing antibody quality, specificity, and functionality.
- Molecular Biology Techniques: Strong skills in DNA manipulation, PCR, cloning, gene expression, and recombinant protein expression.
- Cell Culture Techniques: Experience in cell culture, including maintaining cell lines, transfection/transduction methods, and mammalian expression systems.
- Analytical Techniques: Proficiency in flow cytometry, SPR, BLI, ELISAs, and other analytical methods for antibody screening, characterization, and affinity determination.
- Antibody Engineering: Proficiency in antibody engineering techniques, including structure and function, library construction, screening, humanization, affinity maturation, and production/purification.
- Immunology Knowledge: Solid understanding of antigen-antibody interactions, immune response mechanisms, antibody isotypes, and immunological assays.
- Bioinformatics and Data Analysis: Proficiency in bioinformatics tools for analyzing antibody sequences, predicting antigen binding sites, and interpreting experimental data.
- Problem-Solving and Experimental Design: Strong problem-solving skills and ability to optimize experiments, enhancing antibody affinity, specificity, and stability.
Career Development
Candidates can expect active mentorship and a positive, success-oriented work environment, providing opportunities for professional growth and development in both academic and industry career paths. Regular meetings with the Principal Investigator (PI) will ensure that mutual expectations are met. Engaging in the latest advancements, scientific literature, conferences, and scientific communities is encouraged. Additional resume-building activities will be encouraged to support the goal of becoming an independent faculty or research scientist.
Application: Applications will be accepted until a suitable candidate has been selected. Interested applicants should email a cover letter, an updated CV, complete contact information for three references (1-2 pages) to nsci-hr@neuralsci.org
Research Technician: Intrabody Therapeutics
We are seeking a highly motivated Research Technician to join the Butler lab.
Research:
Join our team in investigating the shared molecular pathway of protein misfolding in various neurodegenerative diseases. Your role will involve supporting the development of immunotherapeutics through targeted degradation of huntingtin, synuclein, and tau proteins to reduce cellular toxicity. We are a multidisciplinary lab that utilizes recombinant antibody technologies, CRISPR-edited iPSCs, iPSC-derived organoids, RNASeq/single-cell transcriptome analysis, immunoprecipitation, FACS sorting, and immunofluorescence.
Requirements:
We seek a highly motivated individual with a Bachelor’s or Master’s degree in a relevant field, preferably with prior laboratory experience.
Ideal Candidate Will Possess:
- Laboratory Skills: Proficiency in basic laboratory techniques, including molecular biology (PCR, cloning), protein characterization (Western blotting, ELISA), and cell culture (cell line maintenance).
- Antibody Techniques: Familiarity with antibody-related techniques such as antibody production and purification, immunoassays, and antibody screening methods.
- Analytical Techniques: Basic knowledge of analytical techniques used in antibody engineering, such as flow cytometry, ELISAs, and data analysis.
- Research Aptitude: Strong problem-solving skills, attention to detail, and ability to work effectively as part of a team.
- Adaptability: Willingness to learn new techniques and assist with various aspects of the research project.
- Communication: Good written and verbal communication skills to effectively document experiments and collaborate with team members.
Career Development:
As a Research Technician, you will receive guidance and mentorship from experienced researchers. Opportunities to expand your knowledge and skills will be provided, supporting your professional growth in the field.
Application:
Applications will be accepted until a suitable candidate is selected. Interested applicants should email a cover letter, updated CV, and contact information for two references to nsci-hr@neuralsci.org